Overactive Bladder
Overactive bladder is defined as a sudden urge to void in association with or without incontinence in the daytime or at night in the absence of a urinary tract infection or another pathologic condition.
It is reported that 445 million people are suffering from overactive bladder all around the world.
Although the underlying cause of the condition is not clearly known, it is considered that disorders in nerves responsible for functioning of the urinary bladder, smooth muscles of the bladder and cells lining the interior surface of the bladder cause overactive bladder.
The incidence is almost same in men and women, but it has been identified that postmenopausal hormonal changes aggravate the complaints.
Overactive bladder is associated with high prevalence of depression, loss of sexual drive and poor work performance.
Although many treatment methods are suggested to treat overactive bladder, medication therapy is essential. The medication therapy implies antimuscarinic agents. Active substances of such medications contain Propiverin, Soliphenacin, Tolterodin, Darifenacin, Trospium and Oxybutinin.
In addition to antimuscarinic drugs, many medication groups including antidepressants have been specified in treatment of overactive bladder, but the antimuscarinic drugs are used primarily.
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